Pancreas Transplant Research Today is a free monthly online journal that collates and summarizes the latest research about Pancreas Transplant, including details on risks, prognosis, procedure, surgery, organ donation.

Organ donor found to have von Hippel-Lindau disease: case report.

Garcia-Roca R, Samame J, Rodriguez C

Department of Hepato-Bilio-Pancreatic, Surgery and Transplantation, Hospital Clinic Barcelona, Barcelona, Spain. raqgar@hotmail.com

Multiple pancreatic cyst in combination with central nervous system hemangioma may be associated with Von Hippel-Lindau disease. The disease manifests with other systemic benign and malignant lesions. The risk of associated malignancy makes it imperative to review target organs before proceeding to transplantation, but does not preclude it completely if proper evaluation is performed. We present a case of an organ donor found to have multiple pancreatic cysts. Evaluation and transplantation decisions are discussed.

Published 22 June 2011 in Transplant Proc, 43(5): 1438-40.
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Articles on Pancreas Transplant published 22 June 2011:

Eculizumab for the treatment of de novo thrombotic microangiopathy post simultaneous pancreas-kidney transplantation--a case report.   Transplant Proc, 43(5): 2097-101.

A 34-year-old female recipient of a simultaneous pancreas-kidney transplant presented 7 days posttransplant with acute renal allograft dysfunction, thrombocytopenia, and microangiopathic hemolytic anemia. Renal biopsy revealed acute antibody-mediated rejection (AMR) and acute thrombotic microangiopathy (TMA). Clinical and laboratory manifestations, which had only partly responded to treatment with daily plasma exchange and intravenous immunoglobulin, resolved rapidly and completely to ... [Abstract] [Full-text]

Myocardial perfusion is a useful screening test for the evaluation of cardiovascular risk in patients undergoing simultaneous pancreas kidney transplantation.   Transplant Proc, 43(5): 1797-800.

Cardiovascular disease is the leading cause of death in simultaneous pancreas kidney transplantation (SPKT) patients. SPKT is increasingly being undertaken to manage patients with advanced diabetic nephropathy and type 1 diabetes mellitus. Traditionally, invasive angiography has been used as a tool to diagnose significant coronary disease and inform decision making with regard to coronary revascularization prior to transplantation. In our retrospective analysis of 167 consecutive patients who ... [Abstract] [Full-text]

A technique for kidney retransplantation after simultaneous kidney pancreas transplantation.   Transplant Proc, 43(5): 1627-8.

Isolated failure of the renal graft after simultaneous kidney-pancreas transplantation (SPK) is a rare but potential outcome. Many of these patients are candidates for kidney retransplantation. This paper describes a series of 3 patients who underwent successful kidney retransplantation after SPK. The operation was completed through an extraperitoneal incision without disruption of the pancreas graft or need for a transplant nephrectomy. [Abstract] [Full-text]

Articles on Pancreas Transplant published 10 June 2011:

Effects of pancreas transplantation on the prevention and reversal of diabetic nephropathy.   Contrib Nephrol, 170: 237-46.

Pancreas transplantation (PTx) is the only available treatment which is able to restore normoglycemia without exposing patients to the risks of severe hypoglycemia, thus allowing testing the effects of very long-term euglycemia in preventing, halting and reversing diabetic nephropathy (DN). Pancreas and islet transplantation in animal models have been shown to prevent, ameliorate or reverse the development of DN lesions. PTx, performed simultaneously or shortly after kidney transplantation in ... [Abstract] [Full-text]

Articles on Pancreas Transplant published 9 June 2011:

Growth of a nation part I: impact of organ donor obesity on whole-organ pancreas transplantation.   Clin Transplant, 25(3): E225-32.

Obesity has reached epidemic proportions in the USA. Consequently, there are an increasing number of potential organ donors that are obese, but would otherwise be appropriate donors for pancreas transplantation (PTx). This is a retrospective study of all PTx performed at Indiana University between 2003 and 2009 (n = 308) comparing donors with body mass index (BMI) <25, 25-29.9, and ≥30 kg/m(2) . Data included recipient and donor demographics, seven and 90-d graft loss, one-yr pancreas, ... [Abstract] [Full-text]

Articles on Pancreas Transplant published 30 May 2011:

Incisional hernia after simultaneous pancreas kidney tranplantation: a single-center experience from Budapest.   Transplant Proc, 43(4): 1303-5.

[Abstract] [Full-text]

Pulmonary tuberculosis in an HIV- and hepatitis C virus-coinfected kidney-pancreas transplant recipient: a case report.   Transplant Proc, 43(4): 1206-9.

Tuberculosis (TB) is a serious infection in immunocompromised patients, such as solid organ transplant recipients and HIV-infected patients. The diagnosis and treatment in this population present several challenges because of the aspecific clinical manifestations, the difficulty in diagnosis, and the choice of the most appropriate therapeutic regimen. Therapeutic challenges arise from drug-related toxicities, interactions between immunosuppressive, antiretroviral, and antituberculous drugs. We ... [Abstract] [Full-text]

Articles on Pancreas Transplant published 19 May 2011:

Increased CD64 expression on polymorphonuclear neutrophils indicates infectious complications following solid organ transplantation.   Cytometry A, 79(6): 446-60.

The aim of this study was to evaluate the diagnostic value of monitoring CD64 antigen upregulation on polymorphonuclear neutrophils (PMN) for the identification of infectious complications in the postoperative course of solid organ transplanted patients. Twenty-five kidney, 13 liver, and four pancreas-kidney transplanted patients were included. Beginning with preoperative values up to postoperative values after 3 months for each patient, the PMN CD64 Index, HLA-DR on monocytes, NKp44+ NK and ... [Abstract] [Full-text]

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