Pancreas Transplant Research Today is a free monthly online journal that collates and summarizes the latest research about Pancreas Transplant, including details on risks, prognosis, procedure, surgery, organ donation. | ||||||||
|
Hyperglycemia and diabetic renal change in a model of polyvinyl alcohol bioartificial pancreas transplantation.Sakata N, Sumi S, Gu Y, Qi M, Yamamoto C, Sunamura M, Egawa S, Unno M, Matsuno S, Inoue K Department of Organ Reconstruction and Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Shogoin-Kawara-cho, Sakyo-ku, Kyoto, Japan. OBJECTIVES: We have developed a bioartificial pancreas transplantation method using polyvinyl alcohol. Using this model, the relationship between hyperglycemia and parameters that represent renal function was investigated. METHODS: Plasma glucose, 1,5-anhydro-d-glucitol (1,5-AG), and renal factors including plasma urea nitrogen and creatinine levels, urine volume, glucose, and albumin were examined once a week for 9 weeks in diabetic mice with or without transplantation of encapsulated rat islets, and in normal C57BL/6 mice. The mesangial matrix fraction of the glomerulus was measured histologically. The mice were classified into 3 groups according to their mean plasma glucose levels as either severe (n = 17) or mild (n = 23) hyperglycemia or normoglycemia (n = 11). The plasma glucose, renal factors, and mesangial matrix fraction were tested by single and multiple regression analyses. RESULTS: Almost all the renal factors correlated significantly with mean plasma glucose and 1,5-AG levels. The level and duration of hyperglycemia estimated by the area under the curve above basal correlated most significantly with mesangial matrix fraction. CONCLUSIONS: Bioartificial pancreas transplantation significantly reduced the deterioration of renal factors. The 1,5-AG was useful to predict urine albumin loss. The level and duration of hyperglycemia determined the degree of renal damage, which were reduced by bioartificial pancreas transplantation. Published 20 April 2007 in Pancreas, 34(4): 458-65.
© 2005-2008 Pancreas Transplant Research Today. All Rights Reserved. |
| ||||||
